Chapter 3 · D50–D89 · 401 codes
Diseases of the blood and immune mechanism
Every ICD-10-CM 2026 code in this chapter, grouped by 3-character category. Click any code for its full description and coding context.
D50
D51
- D51Vitamin B12 deficiency anemia
- D51.0Vitamin B12 deficiency anemia due to intrinsic factor deficiency
- D51.1Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria
- D51.2Transcobalamin II deficiency
- D51.3Other dietary vitamin B12 deficiency anemia
- D51.8Other vitamin B12 deficiency anemias
- D51.9Vitamin B12 deficiency anemia, unspecified
D52
D53
D55
- D55Anemia due to enzyme disorders
- D55.0Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- D55.1Anemia due to other disorders of glutathione metabolism
- D55.2Anemia due to disorders of glycolytic enzymes
- D55.21Anemia due to pyruvate kinase deficiency
- D55.29Anemia due to other disorders of glycolytic enzymes
- D55.3Anemia due to disorders of nucleotide metabolism
- D55.8Other anemias due to enzyme disorders
- D55.9Anemia due to enzyme disorder, unspecified
D56
D57
- D57Sickle-cell disorders
- D57.0Hb-SS disease with crisis
- D57.00Hb-SS disease with crisis, unspecified
- D57.01Hb-SS disease with acute chest syndrome
- D57.02Hb-SS disease with splenic sequestration
- D57.03Hb-SS disease with cerebral vascular involvement
- D57.04Hb-SS disease with dactylitis
- D57.09Hb-SS disease with crisis with other specified complication
- D57.1Sickle-cell disease without crisis
- D57.2Sickle-cell/Hb-C disease
- D57.20Sickle-cell/Hb-C disease without crisis
- D57.21Sickle-cell/Hb-C disease with crisis
- D57.211Sickle-cell/Hb-C disease with acute chest syndrome
- D57.212Sickle-cell/Hb-C disease with splenic sequestration
- D57.213Sickle-cell/Hb-C disease with cerebral vascular involvement
- D57.214Sickle-cell/Hb-C disease with dactylitis
- D57.218Sickle-cell/Hb-C disease with crisis with other specified complication
- D57.219Sickle-cell/Hb-C disease with crisis, unspecified
- D57.3Sickle-cell trait
- D57.4Sickle-cell thalassemia
- D57.40Sickle-cell thalassemia without crisis
- D57.41Sickle-cell thalassemia, unspecified, with crisis
- D57.411Sickle-cell thalassemia, unspecified, with acute chest syndrome
- D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration
- D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
- D57.414Sickle-cell thalassemia, unspecified, with dactylitis
- D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
- D57.419Sickle-cell thalassemia, unspecified, with crisis
- D57.42Sickle-cell thalassemia beta zero without crisis
- D57.43Sickle-cell thalassemia beta zero with crisis
- D57.431Sickle-cell thalassemia beta zero with acute chest syndrome
- D57.432Sickle-cell thalassemia beta zero with splenic sequestration
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvement
- D57.434Sickle-cell thalassemia beta zero with dactylitis
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complication
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecified
- D57.44Sickle-cell thalassemia beta plus without crisis
- D57.45Sickle-cell thalassemia beta plus with crisis
- D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
- D57.452Sickle-cell thalassemia beta plus with splenic sequestration
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
- D57.454Sickle-cell thalassemia beta plus with dactylitis
- D57.458Sickle-cell thalassemia beta plus with crisis with other specified complication
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecified
- D57.8Other sickle-cell disorders
- D57.80Other sickle-cell disorders without crisis
- D57.81Other sickle-cell disorders with crisis
- D57.811Other sickle-cell disorders with acute chest syndrome
- D57.812Other sickle-cell disorders with splenic sequestration
- D57.813Other sickle-cell disorders with cerebral vascular involvement
- D57.814Other sickle-cell disorders with dactylitis
- D57.818Other sickle-cell disorders with crisis with other specified complication
- D57.819Other sickle-cell disorders with crisis, unspecified
D58
D59
- D59Acquired hemolytic anemia
- D59.0Drug-induced autoimmune hemolytic anemia
- D59.1Other autoimmune hemolytic anemias
- D59.10Autoimmune hemolytic anemia, unspecified
- D59.11Warm autoimmune hemolytic anemia
- D59.12Cold autoimmune hemolytic anemia
- D59.13Mixed type autoimmune hemolytic anemia
- D59.19Other autoimmune hemolytic anemia
- D59.2Drug-induced nonautoimmune hemolytic anemia
- D59.3Hemolytic-uremic syndrome
- D59.30Hemolytic-uremic syndrome, unspecified
- D59.31Infection-associated hemolytic-uremic syndrome
- D59.32Hereditary hemolytic-uremic syndrome
- D59.39Other hemolytic-uremic syndrome
- D59.4Other nonautoimmune hemolytic anemias
- D59.5Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
- D59.6Hemoglobinuria due to hemolysis from other external causes
- D59.8Other acquired hemolytic anemias
- D59.9Acquired hemolytic anemia, unspecified
D60
D61
- D61Other aplastic anemias and other bone marrow failure syndromes
- D61.0Constitutional aplastic anemia
- D61.01Constitutional (pure) red blood cell aplasia
- D61.02Shwachman-Diamond syndrome
- D61.03Fanconi anemia
- D61.09Other constitutional aplastic anemia
- D61.1Drug-induced aplastic anemia
- D61.2Aplastic anemia due to other external agents
- D61.3Idiopathic aplastic anemia
- D61.8Other specified aplastic anemias and other bone marrow failure syndromes
- D61.81Pancytopenia
- D61.810Antineoplastic chemotherapy induced pancytopenia
- D61.811Other drug-induced pancytopenia
- D61.818Other pancytopenia
- D61.82Myelophthisis
- D61.89Other specified aplastic anemias and other bone marrow failure syndromes
- D61.9Aplastic anemia, unspecified
D62
D63
D64
- D64Other anemias
- D64.0Hereditary sideroblastic anemia
- D64.1Secondary sideroblastic anemia due to disease
- D64.2Secondary sideroblastic anemia due to drugs and toxins
- D64.3Other sideroblastic anemias
- D64.4Congenital dyserythropoietic anemia
- D64.8Other specified anemias
- D64.81Anemia due to antineoplastic chemotherapy
- D64.89Other specified anemias
- D64.9Anemia, unspecified
D65
D66
D67
D68
- D68Other coagulation defects
- D68.0Von Willebrand disease
- D68.00Von Willebrand disease, unspecified
- D68.01Von Willebrand disease, type 1
- D68.02Von Willebrand disease, type 2
- D68.020Von Willebrand disease, type 2A
- D68.021Von Willebrand disease, type 2B
- D68.022Von Willebrand disease, type 2M
- D68.023Von Willebrand disease, type 2N
- D68.029Von Willebrand disease, type 2, unspecified
- D68.03Von Willebrand disease, type 3
- D68.04Acquired von Willebrand disease
- D68.09Other von Willebrand disease
- D68.1Hereditary factor XI deficiency
- D68.2Hereditary deficiency of other clotting factors
- D68.3Hemorrhagic disorder due to circulating anticoagulants
- D68.31Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
- D68.311Acquired hemophilia
- D68.312Antiphospholipid antibody with hemorrhagic disorder
- D68.318Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
- D68.32Hemorrhagic disorder due to extrinsic circulating anticoagulants
- D68.4Acquired coagulation factor deficiency
- D68.5Primary thrombophilia
- D68.51Activated protein C resistance
- D68.52Prothrombin gene mutation
- D68.59Other primary thrombophilia
- D68.6Other thrombophilia
- D68.61Antiphospholipid syndrome
- D68.62Lupus anticoagulant syndrome
- D68.69Other thrombophilia
- D68.8Other specified coagulation defects
- D68.9Coagulation defect, unspecified
D69
- D69Purpura and other hemorrhagic conditions
- D69.0Allergic purpura
- D69.1Qualitative platelet defects
- D69.2Other nonthrombocytopenic purpura
- D69.3Immune thrombocytopenic purpura
- D69.4Other primary thrombocytopenia
- D69.41Evans syndrome
- D69.42Congenital and hereditary thrombocytopenia purpura
- D69.49Other primary thrombocytopenia
- D69.5Secondary thrombocytopenia
- D69.51Posttransfusion purpura
- D69.59Other secondary thrombocytopenia
- D69.6Thrombocytopenia, unspecified
- D69.8Other specified hemorrhagic conditions
- D69.9Hemorrhagic condition, unspecified
D70
D71
D72
- D72Other disorders of white blood cells
- D72.0Genetic anomalies of leukocytes
- D72.1Eosinophilia
- D72.10Eosinophilia, unspecified
- D72.11Hypereosinophilic syndrome [HES]
- D72.110Idiopathic hypereosinophilic syndrome [IHES]
- D72.111Lymphocytic Variant Hypereosinophilic Syndrome [LHES]
- D72.118Other hypereosinophilic syndrome
- D72.119Hypereosinophilic syndrome [HES], unspecified
- D72.12Drug rash with eosinophilia and systemic symptoms syndrome
- D72.18Eosinophilia in diseases classified elsewhere
- D72.19Other eosinophilia
- D72.8Other specified disorders of white blood cells
- D72.81Decreased white blood cell count
- D72.810Lymphocytopenia
- D72.818Other decreased white blood cell count
- D72.819Decreased white blood cell count, unspecified
- D72.82Elevated white blood cell count
- D72.820Lymphocytosis (symptomatic)
- D72.821Monocytosis (symptomatic)
- D72.822Plasmacytosis
- D72.823Leukemoid reaction
- D72.824Basophilia
- D72.825Bandemia
- D72.828Other elevated white blood cell count
- D72.829Elevated white blood cell count, unspecified
- D72.89Other specified disorders of white blood cells
- D72.9Disorder of white blood cells, unspecified
D73
D74
D75
- D75Other and unspecified diseases of blood and blood-forming organs
- D75.0Familial erythrocytosis
- D75.1Secondary polycythemia
- D75.8Other specified diseases of blood and blood-forming organs
- D75.81Myelofibrosis
- D75.82Heparin induced thrombocytopenia (HIT)
- D75.821Non-immune heparin-induced thrombocytopenia
- D75.822Immune-mediated heparin-induced thrombocytopenia
- D75.828Other heparin-induced thrombocytopenia syndrome
- D75.829Heparin-induced thrombocytopenia, unspecified
- D75.83Thrombocytosis
- D75.838Other thrombocytosis
- D75.839Thrombocytosis, unspecified
- D75.84Other platelet-activating anti-PF4 disorders
- D75.89Other specified diseases of blood and blood-forming organs
- D75.9Disease of blood and blood-forming organs, unspecified
- D75.AGlucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
D76
D77
D78
- D78Intraoperative and postprocedural complications of the spleen
- D78.0Intraoperative hemorrhage and hematoma of the spleen complicating a procedure
- D78.01Intraoperative hemorrhage and hematoma of the spleen complicating a procedure on the spleen
- D78.02Intraoperative hemorrhage and hematoma of the spleen complicating other procedure
- D78.1Accidental puncture and laceration of the spleen during a procedure
- D78.11Accidental puncture and laceration of the spleen during a procedure on the spleen
- D78.12Accidental puncture and laceration of the spleen during other procedure
- D78.2Postprocedural hemorrhage of the spleen following a procedure
- D78.21Postprocedural hemorrhage of the spleen following a procedure on the spleen
- D78.22Postprocedural hemorrhage of the spleen following other procedure
- D78.3Postprocedural hematoma and seroma of the spleen following a procedure
- D78.31Postprocedural hematoma of the spleen following a procedure on the spleen
- D78.32Postprocedural hematoma of the spleen following other procedure
- D78.33Postprocedural seroma of the spleen following a procedure on the spleen
- D78.34Postprocedural seroma of the spleen following other procedure
- D78.8Other intraoperative and postprocedural complications of the spleen
- D78.81Other intraoperative complications of the spleen
- D78.89Other postprocedural complications of the spleen
D80
- D80Immunodeficiency with predominantly antibody defects
- D80.0Hereditary hypogammaglobulinemia
- D80.1Nonfamilial hypogammaglobulinemia
- D80.2Selective deficiency of immunoglobulin A [IgA]
- D80.3Selective deficiency of immunoglobulin G [IgG] subclasses
- D80.4Selective deficiency of immunoglobulin M [IgM]
- D80.5Immunodeficiency with increased immunoglobulin M [IgM]
- D80.6Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
- D80.7Transient hypogammaglobulinemia of infancy
- D80.8Other immunodeficiencies with predominantly antibody defects
- D80.9Immunodeficiency with predominantly antibody defects, unspecified
D81
- D81Combined immunodeficiencies
- D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesis
- D81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
- D81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
- D81.3Adenosine deaminase [ADA] deficiency
- D81.30Adenosine deaminase deficiency, unspecified
- D81.31Severe combined immunodeficiency due to adenosine deaminase deficiency
- D81.32Adenosine deaminase 2 deficiency
- D81.39Other adenosine deaminase deficiency
- D81.4Nezelof's syndrome
- D81.5Purine nucleoside phosphorylase [PNP] deficiency
- D81.6Major histocompatibility complex class I deficiency
- D81.7Major histocompatibility complex class II deficiency
- D81.8Other combined immunodeficiencies
- D81.81Biotin-dependent carboxylase deficiency
- D81.810Biotinidase deficiency
- D81.818Other biotin-dependent carboxylase deficiency
- D81.819Biotin-dependent carboxylase deficiency, unspecified
- D81.82Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
- D81.89Other combined immunodeficiencies
- D81.9Combined immunodeficiency, unspecified
D82
- D82Immunodeficiency associated with other major defects
- D82.0Wiskott-Aldrich syndrome
- D82.1Di George's syndrome
- D82.2Immunodeficiency with short-limbed stature
- D82.3Immunodeficiency following hereditary defective response to Epstein-Barr virus
- D82.4Hyperimmunoglobulin E [IgE] syndrome
- D82.8Immunodeficiency associated with other specified major defects
- D82.9Immunodeficiency associated with major defect, unspecified
D83
- D83Common variable immunodeficiency
- D83.0Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
- D83.1Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
- D83.2Common variable immunodeficiency with autoantibodies to B- or T-cells
- D83.8Other common variable immunodeficiencies
- D83.9Common variable immunodeficiency, unspecified
D84
- D84Other immunodeficiencies
- D84.0Lymphocyte function antigen-1 [LFA-1] defect
- D84.1Defects in the complement system
- D84.8Other specified immunodeficiencies
- D84.81Immunodeficiency due to conditions classified elsewhere
- D84.82Immunodeficiency due to drugs and external causes
- D84.821Immunodeficiency due to drugs
- D84.822Immunodeficiency due to external causes
- D84.89Other immunodeficiencies
- D84.9Immunodeficiency, unspecified
D86
- D86Sarcoidosis
- D86.0Sarcoidosis of lung
- D86.1Sarcoidosis of lymph nodes
- D86.2Sarcoidosis of lung with sarcoidosis of lymph nodes
- D86.3Sarcoidosis of skin
- D86.8Sarcoidosis of other sites
- D86.81Sarcoid meningitis
- D86.82Multiple cranial nerve palsies in sarcoidosis
- D86.83Sarcoid iridocyclitis
- D86.84Sarcoid pyelonephritis
- D86.85Sarcoid myocarditis
- D86.86Sarcoid arthropathy
- D86.87Sarcoid myositis
- D86.89Sarcoidosis of other sites
- D86.9Sarcoidosis, unspecified
D89
- D89Other disorders involving the immune mechanism, not elsewhere classified
- D89.0Polyclonal hypergammaglobulinemia
- D89.1Cryoglobulinemia
- D89.2Hypergammaglobulinemia, unspecified
- D89.3Immune reconstitution syndrome
- D89.4Mast cell activation syndrome and related disorders
- D89.40Mast cell activation, unspecified
- D89.41Monoclonal mast cell activation syndrome
- D89.42Idiopathic mast cell activation syndrome
- D89.43Secondary mast cell activation
- D89.44Hereditary alpha tryptasemia
- D89.49Other mast cell activation disorder
- D89.8Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.81Graft-versus-host disease
- D89.810Acute graft-versus-host disease
- D89.811Chronic graft-versus-host disease
- D89.812Acute on chronic graft-versus-host disease
- D89.813Graft-versus-host disease, unspecified
- D89.82Autoimmune lymphoproliferative syndrome [ALPS]
- D89.83Cytokine release syndrome
- D89.831Cytokine release syndrome, grade 1
- D89.832Cytokine release syndrome, grade 2
- D89.833Cytokine release syndrome, grade 3
- D89.834Cytokine release syndrome, grade 4
- D89.835Cytokine release syndrome, grade 5
- D89.839Cytokine release syndrome, grade unspecified
- D89.84IgG4-related disease
- D89.89Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.9Disorder involving the immune mechanism, unspecified
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